8 nights Italy, Greece, Egypt, Jordan, Saudi Arabia

Rome is the capital city and a special comune of Italy (named Comune di Roma Capitale). Rome also serves as the capital of the Lazio region. With 2,872,800 residents in 1,285 km2(496.1 sq mi), it is also the country's most populated comune. It is the fourth-most populous city in the European Union by population within city limits. It is the centre of the Metropolitan City of Rome, which has a population of 4,355,725 residents, thus making it the most populous metropolitan city in Italy. Rome is located in the central-western portion of the Italian Peninsula, within Lazio (Latium), along the shores of the Tiber. The Vatican City (the smallest country in the world) is an independent country inside the city boundaries of Rome, the only existing example of a country within a city: for this reason Rome has been often defined as capital of two states.

Rome's history spans 28 centuries. While Roman mythology dates the founding of Rome at around 753 BC, the site has been inhabited for much longer, making it one of the oldest continuously occupied sites in Europe. The city's early population originated from a mix of Latins, Etruscans, and Sabines. Eventually, the city successively became the capital of the Roman Kingdom, the Roman Republic and the Roman Empire, and is regarded as the birthplace of Western civilization and by some as the first ever metropolis. It was first called The Eternal City (Latin: Urbs Aeterna; Italian: La Città Eterna) by the Roman poet Tibullus in the 1st century BC, and the expression was also taken up by Ovid, Virgil, and Livy. Rome is also called the "Caput Mundi" (Capital of the World). After the fall of the Western Empire, which marked the beginning of the Middle Ages, Rome slowly fell under the political control of the Papacy, which had settled in the city since the 1st century AD, until in the 8th century it became the capital of the Papal States, which lasted until 1870. Beginning with the Renaissance, almost all the popes since Nicholas V (1447–1455) pursued over four hundred years a coherent architectural and urban programme aimed at making the city the artistic and cultural centre of the world. In this way, Rome became first one of the major centres of the Italian Renaissance, and then the birthplace of both the Baroque style and Neoclassicism. Famous artists, painters, sculptors and architects made Rome the centre of their activity, creating masterpieces throughout the city. In 1871, Rome became the capital of the Kingdom of Italy, which, in 1946, became the Italian Republic.

Rome has the status of a global city. In 2016, Rome ranked as the 14th-most-visited city in the world, 3rd most visited in the European Union, and the most popular tourist attraction in Italy. Its historic centre is listed by UNESCO as a World Heritage Site. The famous Vatican Museums are among the world's most visited museums while the Colosseum was the most popular tourist attraction in world with 7.4 million visitors in 2018. Host city for the 1960 Summer Olympics, Rome is the seat of several specialized agencies of the United Nations, such as the Food and Agriculture Organization (FAO), the World Food Programme (WFP) and the International Fund for Agricultural Development (IFAD). The city also hosts the Secretariat of the Parliamentary Assembly of the Union for the Mediterranean (UfM) as well as the headquarters of many international business companies such as Eni, Enel, TIM, Leonardo S.p.A., and national and international banks such as Unicredit and BNL. Its business district, called EUR, is the base of many companies involved in the oil industry, the pharmaceutical industry, and financial services. Rome is also an important fashion and design centre thanks to renowned international brands centered in the city. Rome's Cinecittà Studios have been the set of many Academy Award–winning movies.

Heraklion or Heraclion is the largest city and the administrative capital of the island of Crete. It is the fourth largest city in Greece. According to the results of the 2011 census, the population of the city proper was 166,209 inhabitants, the municipality's was 173,993 while the Heraklion urban area has a population of 225,574 and it extends over an area of 684.3 km2 (264.2 sq mi).

Heraklion is the capital of Heraklion regional unit.

The Bronze Age palace of Knossos, also known as the Palace of Minos, is located nearby.

The Suez Canal is a sea-level waterway in Egypt, connecting the Mediterranean Sea to the Red Sea through the Isthmus of Suez. Constructed by the Suez Canal Company between 1859 and 1869, it was officially opened on 17 November 1869. The canal offers watercraft a shorter journey between the North Atlantic and northern Indian Oceans via the Mediterranean and Red Seas by avoiding the South Atlantic and southern Indian Oceans, reducing the journey by approximately 6,000 kilometres (3,700 mi). It extends from the northern terminus of Port Said to the southern terminus of Port Tewfik at the city of Suez. Its length is 193.30 km (120.11 mi), including its northern and southern access channels. In 2012, 17,225 vessels traversed the canal (average 47 per day).

The Suez Canal is a sea-level waterway in Egypt, connecting the Mediterranean Sea to the Red Sea through the Isthmus of Suez. Constructed by the Suez Canal Company between 1859 and 1869, it was officially opened on 17 November 1869. The canal offers watercraft a shorter journey between the North Atlantic and northern Indian Oceans via the Mediterranean and Red Seas by avoiding the South Atlantic and southern Indian Oceans, reducing the journey by approximately 6,000 kilometres (3,700 mi). It extends from the northern terminus of Port Said to the southern terminus of Port Tewfik at the city of Suez. Its length is 193.30 km (120.11 mi), including its northern and southern access channels. In 2012, 17,225 vessels traversed the canal (average 47 per day).

Aqaba is the only coastal city in Jordan and the largest and most populous city on the Gulf of Aqaba. Situated in southernmost Jordan, Aqaba is the administrative centre of the Aqaba Governorate. The city had a population of 148,398 in 2015 and a land area of 375 square kilometres (144.8 sq mi). Today, Aqaba plays a major role in the development of the Jordanian economy, through the vibrant trade and tourism sectors. The Port of Aqaba also serves other countries in the region.

Aqaba's strategic location at the northeastern tip of the Red Sea between the continents of Asia and Africa, has made its port important over the course of thousands of years.