Cape Town is the oldest city in South Africa, colloquially named the Mother City. It is the legislative capital of South Africa and primate city of the Western Cape province. It forms part of the City of Cape Town metropolitan municipality.

The Parliament of South Africa sits in Cape Town. The other two capitals are located in Pretoria (the administrative capital where the Presidency is based) and Bloemfontein (the judicial capital where the Supreme Court of Appeal is located). The city is known for its harbour, for its natural setting in the Cape Floristic Region, and for landmarks such as Table Mountain and Cape Point. As of 2014, it is the 10th most populous city in Africa and home to 64% of the Western Cape's population. It is one of the most multicultural cities in the world, reflecting its role as a major destination for immigrants and expatriates to South Africa. The city was named the World Design Capital for 2014 by the International Council of Societies of Industrial Design. In 2014, Cape Town was named the best place in the world to visit by both The New York Times and The Daily Telegraph.

Located on the shore of Table Bay, Cape Town, as the oldest urban area in South Africa, was developed by the Dutch East India Company (VOC) as a supply station for Dutch ships sailing to East Africa, India, and the Far East. Jan van Riebeeck's arrival on 6 April 1652 established Dutch Cape Colony, the first permanent European settlement in South Africa. Cape Town outgrew its original purpose as the first European outpost at the Castle of Good Hope, becoming the economic and cultural hub of the Cape Colony. Until the Witwatersrand Gold Rush and the development of Johannesburg, Cape Town was the largest city in South Africa.

Durban is the third most populous city in South Africa—after Johannesburg and Cape Town—and the largest city in the South African province of KwaZulu-Natal. Located on the east coast of South Africa, Durban is famous for being the busiest port in the country. It is also seen as one of the major centres of tourism because of the city's warm subtropical climate and extensive beaches. Durban forms part of the eThekwini Metropolitan Municipality, which includes neighboring towns and has a population of about 3.44 million, making the combined municipality one of the biggest cities on the Indian Ocean coast of the African continent. It is also the second most important manufacturing hub in South Africa after Johannesburg. In 2015, Durban was recognised as one of the New7Wonders Cities (along with Vigan, Doha, La Paz, Havana, Beirut, and Kuala Lumpur).