Charleston is the oldest and largest city in the U.S. state of South Carolina, the county seat of Charleston County, and the principal city in the Charleston–North Charleston–Summerville Metropolitan Statistical Area.The city lies just south of the geographical midpoint of South Carolina's coastline and is located on Charleston Harbor, an inlet of the Atlantic Ocean formed by the confluence of the Ashley, Cooper, and Wando rivers. Charleston had an estimated population of 134,875 in 2017. The estimated population of the Charleston metropolitan area, comprising Berkeley, Charleston, and Dorchester counties, was 761,155 residents in 2016, the third-largest in the state and the 78th-largest metropolitan statistical area in the United States.

Charleston was founded in 1670 as Charles Town, honoring King Charles II of England. Its initial location at Albemarle Point on the west bank of the Ashley River (now Charles Towne Landing) was abandoned in 1680 for its present site, which became the fifth-largest city in North America within ten years. Despite its size, it remained unincorporated throughout the colonial period; its government was handled directly by a colonial legislature and a governor sent by London. Election districts were organized according to Anglican parishes, and some social services were managed by Anglican wardens and vestries. Charleston adopted its present spelling with its incorporation as a city in 1783 at the close of the Revolutionary War. Population growth in the interior of South Carolina influenced the removal of the state government to Columbia in 1788, but the port city remained among the ten largest cities in the United States through the 1840 census. Historians estimate that "nearly half of all Africans brought to America arrived in Charleston", most at Gadsden's Wharf. The only major antebellum American city to have a majority-enslaved population, Charleston was controlled by an oligarchy of white plantersand merchants who successfully forced the federal government to revise its 1828 and 1832 tariffs during the Nullification Crisis and launched the Civil War in 1861 by seizing the Arsenal, Castle Pinckney, and Fort Sumterfrom their federal garrisons.

Known for its rich history, well-preserved architecture, distinguished restaurants, and hospitable people, Charleston is a popular tourist destination. It has received numerous accolades, including "America's Most Friendly [City]" by Travel + Leisure in 2011 and in 2013 and 2014 by Condé Nast Traveler, and also "the most polite and hospitable city in America" by Southern Living magazine. In 2016, Charleston was ranked the "World's Best City" by Travel + Leisure.

Miami, officially the City of Miami, is the cultural, economic and financial center of South Florida. Miami is the seat of Miami-Dade County, the most populous county in Florida. The city covers an area of about 56.6 square miles (147 km2), between the Everglades to the west and Biscayne Bay on the east; with a 2017 estimated population of 463,347, Miami is the sixth most densely populated major city in the United States. The Miami metropolitan area is home to 6.1 million people and the seventh-largest metropolitan area in the nation. Miami's metro area is the second-most populous metropolis in the southeastern United States and fourth-largest urban area in the U.S.

Miami is a major center, and a leader in finance, commerce, culture, media, entertainment, the arts, and international trade. The Miami Metropolitan Area is by far the largest urban economy in Florida and the 12th largest in the United States with a GDP of $344.9 billion as of 2017. In 2012, Miami was classified as an "Alpha−" level world city in the World Cities Study Group's inventory. In 2010, Miami ranked seventh in the United States and 33rd among global cities in terms of business activity, human capital, information exchange, cultural experience, and political engagement. In 2008, Forbes magazine ranked Miami "America's Cleanest City", for its year-round good air quality, vast green spaces, clean drinking water, clean streets, and citywide recycling programs. According to a 2009 UBS study of 73 world cities, Miami was ranked as the richest city in the United States, and the world's seventh-richest city in terms of purchasing power. Miami is nicknamed the "Capital of Latin America" and is the largest city with a Cuban-American plurality.

Greater Downtown Miami has one of the largest concentrations of international banks in the United States, and is home to many large national and international companies. The Civic Center is a major center for hospitals, research institutes, medical centers, and biotechnology industries. For more than two decades, the Port of Miami, known as the "Cruise Capital of the World", has been the number one cruise passenger port in the world. It accommodates some of the world's largest cruise ships and operations, and is the busiest port in both passenger traffic and cruise lines. Metropolitan Miami is also a major tourism hub in the southeastern U.S. for international visitors, ranking number two in the country after New York City.