Genoa is the capital of the Italian region of Liguria and the sixth-largest city in Italy. In 2015, 594,733 people lived within the city's administrative limits. As of the 2011 Italian census, the Province of Genoa, which in 2015 became the Metropolitan City of Genoa, counted 855,834 resident persons. Over 1.5 million people live in the wider metropolitan area stretching along the Italian Riviera.

 Located on the Gulf of Genoa in the Ligurian Sea, Genoa has historically been one of the most important ports on the Mediterranean: it is currently the busiest in Italy and in the Mediterranean Sea and twelfth-busiest in the European Union. Genoa has been nicknamed la Superba ("the proud one") due to its glorious past and impressive landmarks. Part of the old town of Genoa was inscribed on the World Heritage List (UNESCO) in 2006 as Genoa: Le Strade Nuove and the system of the Palazzi dei Rolli. The city's rich cultural history in art, music and cuisine allowed it to become the 2004 European Capital of Culture. It is the birthplace of Christopher Columbus, Andrea Doria, Niccolò Paganini, Giuseppe Mazzini, Renzo Piano and Grimaldo Canella, founder of the House of Grimaldi, among others.

Genoa, which forms the southern corner of the Milan-Turin-Genoa industrial triangle of Northwest Italy, is one of the country's major economic centers. The city has hosted massive shipyards and steelworks since the 19th century, and its solid financial sector dates back to the Middle Ages. The Bank of Saint George, founded in 1407, is among the oldest in the world and has played an important role in the city's prosperity since the middle of the 15th century. Today a number of leading Italian companies are based in the city, including Fincantieri, Selex ES, Ansaldo Energia, Ansaldo STS, Edoardo Raffinerie Garrone, Piaggio Aerospace, Mediterranean Shipping Company and Costa Cruises.

Naples is the regional capital of Campania and the third-largest municipality in Italyafter Rome and Milan. In 2017, around 967,069 people lived within the city's administrative limits while its province-level municipality has a population of 3,115,320 residents. Its continuously built-up metropolitan area (that stretches beyond the boundaries of the Metropolitan City of Naples) is the second or third largest metropolitan area in Italy and one of the most densely populated cities in Europe.

First settled by Greeks in the second millennium BC, Naples is one of the oldest continuously inhabited urban areas in the world. In the ninth century BC, a colony known as Parthenope or Παρθενόπη was established on the Island of Megaride, later refounded as Neápolis in the sixth century BC. The city was an important part of Magna Graecia, played a major role in the merging of Greek and Roman society and a significant cultural centre under the Romans. It served as the capital of the Duchy of Naples (661–1139), then of the Kingdom of Naples (1282–1816) and finally of the Two Sicilies until the unification of Italy in 1861.

Between 1925 and 1936, Naples was expanded and upgraded by Benito Mussolini's government but subsequently sustained severe damage from Allied bombing during World War II, which led to extensive post-1945 reconstruction work. Naples has experienced significant economic growth in recent decades, helped by the construction of the Centro Direzionale business district and an advanced transportation network, which includes the Alta Velocità high-speed rail link to Rome and Salerno and an expanded subway network. Naples is the third-largest urban economy in Italy, after Milan and Rome. The Port of Naples is one of the most important in Europe and home of the Allied Joint Force Command Naples, the NATO body that oversees North Africa, the Sahel and Middle East.

Naples' historic city centre is the largest in Europe and a UNESCO World Heritage Site, with a wide range of culturally and historically significant sites nearby, including the Palace of Caserta and the Roman ruins of Pompeii and Herculaneum. Naples is also known for its natural beauties such as Posillipo, Phlegraean Fields, Nisida, and Vesuvius.

Neapolitan cuisine is synonymous with pizza – which originated in the city – but it also includes many lesser-known dishes; Naples has the greatest number of accredited stars from the Michelin Guide of any Italian city.

The best-known sports team in Naples is the Serie A club S.S.C. Napoli, two-time Italian champions who play at the San Paolo Stadium in the southwest of the city, in the Fuorigrotta quarter.

Heraklion or Heraclion is the largest city and the administrative capital of the island of Crete. It is the fourth largest city in Greece. According to the results of the 2011 census, the population of the city proper was 166,209 inhabitants, the municipality's was 173,993 while the Heraklion urban area has a population of 225,574 and it extends over an area of 684.3 km2 (264.2 sq mi).

Heraklion is the capital of Heraklion regional unit.

The Bronze Age palace of Knossos, also known as the Palace of Minos, is located nearby.

Santorini, classically Thera, and officially Thira, is an island in the southern Aegean Sea, about 200 km (120 mi) southeast of Greece's mainland. It is the largest island of a small, circular archipelago, which bears the same name and is the remnant of a volcanic caldera. It forms the southernmost member of the Cyclades group of islands, with an area of approximately 73 km2 (28 sq mi) and a 2011 census population of 15,550. The municipality of Santorini includes the inhabited islands of Santorini and Therasia and the uninhabited islands of Nea Kameni, Palaia Kameni, Aspronisi, and Christiana. The total land area is 90.623 km2 (34.990 sq mi).Santorini is part of the Thira regional unit.

The island was the site of one of the largest volcanic eruptions in recorded history: the Minoan eruption(sometimes called the Thera eruption), which occurred about 3,600 years ago at the height of the Minoan civilization. The eruption left a large caldera surrounded by volcanic ash deposits hundreds of metres deep. It may have led indirectly to the collapse of the Minoan civilization on the island of Crete, 110 km (68 mi) to the south, through a gigantic tsunami. Another popular theory holds that the Thera eruption is the source of the legend of Atlantis.

It is the most active volcanic centre in the South Aegean Volcanic Arc, though what remains today is chiefly a water-filled caldera. The volcanic arc is approximately 500 km (310 mi) long and 20 to 40 km (12 to 25 mi) wide. The region first became volcanically active around 3–4 million years ago[citation needed], though volcanism on Thera began around 2 million years ago with the extrusion of dacitic lavas from vents around the Akrotiri.

Bari is the capital city of the Metropolitan City of Bari and of the Apulia region, on the Adriatic Sea, in southern Italy. It is the second most important economic centre of mainland Southern Italy after Naples and Palermo, a port and universitycity, as well as the city of Saint Nicholas. The city itself has a population of 326,799, as of 2015, over 116 square kilometres (45 sq mi), while the urban area has 700,000 inhabitants. The metropolitan area has 1.3 million inhabitants.

Bari is made up of four different urban sections. To the north is the closely built old town on the peninsula between two modern harbours, with the Basilica of Saint Nicholas, the Cathedral of San Sabino (1035–1171) and the Hohenstaufen Castle built for Frederick II, which is now also a major nightlife district. To the south is the Murat quarter (erected by Joachim Murat), the modern heart of the city, which is laid out on a rectangular grid-plan with a promenade on the sea and the major shopping district (the via Sparano and via Argiro).

Modern residential zones surrounding the centre of Bari were built during the 1960s and 1970s replacing the old suburbs that had developed along roads splaying outwards from gates in the city walls. In addition, the outer suburbs developed rapidly during the 1990s. The city has a redeveloped airport named after Pope John Paul II, Karol Wojtyła Airport, with connections to several European cities.