15 nights, from Miami, Florida

Miami, officially the City of Miami, is the cultural, economic and financial center of South Florida. Miami is the seat of Miami-Dade County, the most populous county in Florida. The city covers an area of about 56.6 square miles (147 km2), between the Everglades to the west and Biscayne Bay on the east; with a 2017 estimated population of 463,347, Miami is the sixth most densely populated major city in the United States. The Miami metropolitan area is home to 6.1 million people and the seventh-largest metropolitan area in the nation. Miami's metro area is the second-most populous metropolis in the southeastern United States and fourth-largest urban area in the U.S.

Miami is a major center, and a leader in finance, commerce, culture, media, entertainment, the arts, and international trade. The Miami Metropolitan Area is by far the largest urban economy in Florida and the 12th largest in the United States with a GDP of $344.9 billion as of 2017. In 2012, Miami was classified as an "Alpha−" level world city in the World Cities Study Group's inventory. In 2010, Miami ranked seventh in the United States and 33rd among global cities in terms of business activity, human capital, information exchange, cultural experience, and political engagement. In 2008, Forbes magazine ranked Miami "America's Cleanest City", for its year-round good air quality, vast green spaces, clean drinking water, clean streets, and citywide recycling programs. According to a 2009 UBS study of 73 world cities, Miami was ranked as the richest city in the United States, and the world's seventh-richest city in terms of purchasing power. Miami is nicknamed the "Capital of Latin America" and is the largest city with a Cuban-American plurality.

Greater Downtown Miami has one of the largest concentrations of international banks in the United States, and is home to many large national and international companies. The Civic Center is a major center for hospitals, research institutes, medical centers, and biotechnology industries. For more than two decades, the Port of Miami, known as the "Cruise Capital of the World", has been the number one cruise passenger port in the world. It accommodates some of the world's largest cruise ships and operations, and is the busiest port in both passenger traffic and cruise lines. Metropolitan Miami is also a major tourism hub in the southeastern U.S. for international visitors, ranking number two in the country after New York City.

The city of Cartagena, known in the colonial era as Cartagena de Indias, is a major port founded in 1533, located on the northern coast of Colombia in the Caribbean Coast Region. It was strategically located between the Magdalena and Sinú rivers and became the main port for trade between Spain and its overseas empire, establishing its importance by the early 1540s. During the colonial era it was a key port for the export of Peruvian silver to Spain and for the import of enslaved Africans under the asiento system. It was defensible against pirate attacks in the Caribbean. It is the capital of the Bolívar Department, and had a population 971,592 as of 2016. It is the fifth-largest city in Colombia and the second largest in the region, after Barranquilla. The urban area of Cartagena is also the fifth-largest urban area in the country. Economic activities include the maritime and petrochemicals industries, as well as tourism.

The city was founded on June 1, 1533, and named after Cartagena, Spain, settlement in the region around Cartagena Bay by various indigenous people dates back to 4000 BC. During the Spanish colonial period Cartagena served a key role in administration and expansion of the Spanish empire. It was a center of political, ecclesiastical, and economic activity. In 1984, Cartagena's colonial walled city and fortress were designated a UNESCO World Heritage Site.

The Panama Canal is an artificial 82 km (51 mi) waterway in Panama that connects the Atlantic Ocean with the Pacific Ocean. The canal cuts across the Isthmus of Panama and is a conduit for maritime trade. Canal locks are at each end to lift ships up to Gatun Lake, an artificial lake created to reduce the amount of excavation work required for the canal, 26 m (85 ft) above sea level, and then lower the ships at the other end. The original locks are 34 m (110 ft) wide. A third, wider lane of locks was constructed between September 2007 and May 2016. The expanded canal began commercial operation on June 26, 2016. The new locks allow transit of larger, post-Panamax ships, capable of handling more cargo.

France began work on the canal in 1881, but stopped due to engineering problems and a high worker mortality rate. The United States took over the project in 1904 and opened the canal on August 15, 1914. One of the largest and most difficult engineering projects ever undertaken, the Panama Canal shortcut greatly reduced the time for ships to travel between the Atlantic and Pacific Oceans, enabling them to avoid the lengthy, hazardous Cape Horn route around the southernmost tip of South America via the Drake Passage or Strait of Magellan.

Colombia, France, and later the United States controlled the territory surrounding the canal during construction. The US continued to control the canal and surrounding Panama Canal Zone until the 1977 Torrijos–Carter Treatiesprovided for handover to Panama. After a period of joint American–Panamanian control, in 1999, the canal was taken over by the Panamanian government. It is now managed and operated by the government-owned Panama Canal Authority.

Puntarenas is the capital and largest city in the Province of Puntarenas, on the Pacific coast of Costa Rica.

Puerto Vallarta is a Mexican beach resort city situated on the Pacific Ocean's Bahía de Banderas. PV or simply Vallarta is the second largest urban agglomeration in the state after the Guadalajara Metropolitan Area. The City of Puerto Vallarta is the government seat of the Municipality of Puerto Vallarta which comprises the city as well as population centers outside of the city extending from Boca de Tomatlán to the Nayarit border (the Ameca River). The city is located at 20°40′N 105°16′W. The municipality has an area of 1,300.7 square kilometres (502.19 sq mi). To the north it borders the southwest part of the state of Nayarit. To the east it borders the municipality of Mascota and San Sebastián del Oeste, and to the south it borders the municipalities of Talpa de Allende and Cabo Corrientes.

Puerto Vallarta is named after Ignacio Vallarta, a former governor of Jalisco. In Spanish, Puerto Vallarta is frequently shortened to "Vallarta", while English speakers call the city P.V. for short. In internet shorthand the city is often referred to as PVR, after the International Air Transport Association airport code for its Gustavo Diaz Ordaz International Airport.

Cabo San Lucas  or simply Cabo, is a resort city at the southern tip of the Baja California Peninsula, in the Mexican state of Baja California Sur. As of 2015, the population of the city was 81,111 inhabitants. Cabo San Lucas together with San José del Cabo is known as Los Cabos. Together they form a metropolitan area of 305,983 inhabitants.

Cabo has been rated as one of Mexico's top 5 tourist destinations; it is known for its beaches, scuba diving locations, balnearios, the sea arch El Arco de Cabo San Lucas, and marine life. The Los Cabos Corridor has become a heavily trafficked vacation destination for tourists, with numerous resorts and timeshares along the coast between Cabo San Lucas and San José del Cabo.

Cabo houses a range of wildlife, including rays, sharks, birds, and a range of fish, such as mahi-mahi (dorado), and striped marlin.

Los Angeles officially the City of Los Angeles and often known colloquially by its initials L.A., is the most populous city in California and the second most populous city in the United States, after New York. With an estimated population of four million, Los Angeles is the cultural, financial, and commercial center of Southern California. Nicknamed the "City of Angels" partly because of its name's Spanish meaning, Los Angeles is known for its Mediterranean climate, ethnic diversity, Hollywood, and the entertainment industry, and sprawling metropolis.

Los Angeles is in a large basin bounded by the Pacific Ocean on one side and by mountains as high as 10,000 feet (3,000 m) on the others. The city proper, which covers about 469 square miles (1,210 km2), is the seat of Los Angeles County, the most populated county in the country. Los Angeles is also the principal city of the Los Angeles metropolitan area, the second largest in the United States after that of New York City, with a population of 13.1 million. It is part of the Los Angeles-Long Beach combined statistical area, also the nation's second most populous area with a 2015 estimated population of 18.7 million.

Los Angeles is one of the most substantial economic engines within the United States, with a diverse economy in a broad range of professional and cultural fields. Los Angeles is also famous as the home of Hollywood, a major center of the world entertainment industry. A global city, it has been ranked 6th in the Global Cities Index and 9th in the Global Economic Power Index. The Los Angeles combined statistical area also has a gross metropolitan productof $831 billion (as of 2008), making it the third-largest in the world, after the Tokyo and New York metropolitan areas. Los Angeles hosted the 1932 and 1984 Summer Olympics and will host the event for a third time in 2028. The city also hosted the Miss Universe pageant twice, in 1990 and 2006, and was one of 9 American cities to host the 1994 FIFA men's soccer World Cup and one of 8 to host the 1999 FIFA women's soccer World Cup, hosting the finalmatch for both tournaments.

Historically home to the Chumash and Tongva, Los Angeles was claimed by Juan Rodríguez Cabrillo for Spain in 1542 along with the rest of what would become Alta California. The city was officially founded on September 4, 1781, by Spanish governor Felipe de Neve. It became a part of Mexico in 1821 following the Mexican War of Independence. In 1848, at the end of the Mexican–American War, Los Angeles and the rest of California were purchased as part of the Treaty of Guadalupe Hidalgo, becoming part of the United States. Los Angeles was incorporated as a municipality on April 4, 1850, five months before California achieved statehood. The discovery of oil in the 1890s brought rapid growth to the city. The completion of the Los Angeles Aqueduct in 1913, delivering water from Eastern California, later assured the city's continued rapid growth.