10 nights, from Panama City Florida

The city of Cartagena, known in the colonial era as Cartagena de Indias, is a major port founded in 1533, located on the northern coast of Colombia in the Caribbean Coast Region. It was strategically located between the Magdalena and Sinú rivers and became the main port for trade between Spain and its overseas empire, establishing its importance by the early 1540s. During the colonial era it was a key port for the export of Peruvian silver to Spain and for the import of enslaved Africans under the asiento system. It was defensible against pirate attacks in the Caribbean. It is the capital of the Bolívar Department, and had a population 971,592 as of 2016. It is the fifth-largest city in Colombia and the second largest in the region, after Barranquilla. The urban area of Cartagena is also the fifth-largest urban area in the country. Economic activities include the maritime and petrochemicals industries, as well as tourism.

The city was founded on June 1, 1533, and named after Cartagena, Spain, settlement in the region around Cartagena Bay by various indigenous people dates back to 4000 BC. During the Spanish colonial period Cartagena served a key role in administration and expansion of the Spanish empire. It was a center of political, ecclesiastical, and economic activity. In 1984, Cartagena's colonial walled city and fortress were designated a UNESCO World Heritage Site.

New Orleans is a consolidated city-parish located along the Mississippi River in the southeastern region of the U.S. state of Louisiana. With an estimated population of 393,292 in 2017, it is the most populous city in Louisiana. A major port, New Orleans is considered an economic and commercial hub for the broader Gulf Coast region of the United States.

New Orleans is world-renowned for its distinct music, Creole cuisine, unique dialect, and its annual celebrations and festivals, most notably Mardi Gras. The historic heart of the city is the French Quarter, known for its French and Spanish Creole architecture and vibrant nightlife along Bourbon Street. The city has been described as the "most unique" in the United States, owing in large part to its cross-cultural and multilingual heritage. Founded in 1718 by French colonists, New Orleans was once the territorial capital of French Louisiana before being traded to the United States in the Louisiana Purchase of 1803. New Orleans was once the third-most populous city in the United States, and it was the largest city in the American South from the Antebellum era until after World War II. The city's location and low elevation have historically made it very vulnerable to flooding, leading to the installation of a complex system of levees and drainage pumps.

New Orleans was severely affected by Hurricane Katrina in 2005, flooding over 80% of the city and causing a population decline of over 50%. Since Katrina, major redevelopment efforts have led to a rebound in the city's population. Although, concerns about gentrification, new residents buying property in closely knit communities, and displacement of longtime residents have been voiced.

The city and Orleans Parish (French: paroisse d'Orléans) are coterminous. As of 2017, Orleans Parish is the third most-populous parish in Louisiana, behind East Baton Rouge Parish and neighboring Jefferson Parish. The city and parish are bounded by St. Tammany Parish and Lake Pontchartrain to the north, St. Bernard Parish and Lake Borgne to the east, Plaquemines Parish to the south, and Jefferson Parish to the south and west.

The city anchors the larger New Orleans metropolitan area which had an estimated population of 1,275,762 in 2017, making it the most populous metropolitan area in Louisiana and the 46th-most populated in the United States.

New Orleans is a consolidated city-parish located along the Mississippi River in the southeastern region of the U.S. state of Louisiana. With an estimated population of 393,292 in 2017, it is the most populous city in Louisiana. A major port, New Orleans is considered an economic and commercial hub for the broader Gulf Coast region of the United States.

New Orleans is world-renowned for its distinct music, Creole cuisine, unique dialect, and its annual celebrations and festivals, most notably Mardi Gras. The historic heart of the city is the French Quarter, known for its French and Spanish Creole architecture and vibrant nightlife along Bourbon Street. The city has been described as the "most unique" in the United States, owing in large part to its cross-cultural and multilingual heritage. Founded in 1718 by French colonists, New Orleans was once the territorial capital of French Louisiana before being traded to the United States in the Louisiana Purchase of 1803. New Orleans was once the third-most populous city in the United States, and it was the largest city in the American South from the Antebellum era until after World War II. The city's location and low elevation have historically made it very vulnerable to flooding, leading to the installation of a complex system of levees and drainage pumps.

New Orleans was severely affected by Hurricane Katrina in 2005, flooding over 80% of the city and causing a population decline of over 50%. Since Katrina, major redevelopment efforts have led to a rebound in the city's population. Although, concerns about gentrification, new residents buying property in closely knit communities, and displacement of longtime residents have been voiced.

The city and Orleans Parish (French: paroisse d'Orléans) are coterminous. As of 2017, Orleans Parish is the third most-populous parish in Louisiana, behind East Baton Rouge Parish and neighboring Jefferson Parish. The city and parish are bounded by St. Tammany Parish and Lake Pontchartrain to the north, St. Bernard Parish and Lake Borgne to the east, Plaquemines Parish to the south, and Jefferson Parish to the south and west.

The city anchors the larger New Orleans metropolitan area which had an estimated population of 1,275,762 in 2017, making it the most populous metropolitan area in Louisiana and the 46th-most populated in the United States.